Aliskiren effect on non-alcoholic steatohepatitis in metabolic syndrome

Aliskiren effect on non-alcoholic steatohepatitis in metabolic syndrome

BACKGROUND Non-alcoholic steatohepatitis (NASH) is highly associated with metabolic syndrome, a major cause of morbidity in the globalized society. The renin-angiotensin system (RAS) influences hepatic fatty acid metabolism, inflammation and fibrosis. Thus, in the present study, we aimed to evaluate the effect of aliskiren, a direct renin inhibitor, on metabolic syndrome-related NASH. METHODS...

Predictive factors of non-alcoholic steatohepatitis: relationship with metabolic syndrome.

UNLABELLED Non-alcoholic fatty liver disease (NAFLD) has been proposed as the hepatic manifestation of the metabolic syndrom (Ms), with insulin resistance (IR) as the common pathophysiological mechanism. METHODS We included 145 patients with NAFLD proven liver biopsy. NAS-score was employed to grading NAFLD. We determined anthropometric measurements, basal blood pression (BP), biochemical mea...

Non-alcoholic steatohepatitis

Non-alcoholic steatohepatitis in children.

Non-alcoholic steatohepatitis (NASH) is an important liver disease in children; it can cause cirrhosis in children. The disease mechanism involves hepatic insulin resistance with hyperinsulinemia and changes in certain adipocytokines and inflammatory mediators. The differential diagnosis of childhood NASH includes metabolic disorders, drug hepatotoxicity, and alcoholic hepatitis in adolescent p...

Non-alcoholic steatohepatitis (NASH) – is it a part of the metabolic syndrome?

Metabolic syndrome is one of the most frequent diseases of our age, and it is accompanied by numerous complications. Clinical studies have been published suggesting that, in addition to the already well-known consequences of the metabolic syndrome, hepatic involvement should also be taken into consideration in a significant part of cases. Fatty liver or in most cases the histological picture of...